Solitary Oral Mucosal Neuromas: A Rare Case Report

Mucosal neuromas are a form of neurogenic tumour that arises in the oral cavity as a component of multiple endocrine neoplasia type 2b (MEN 2b). The syndrome is characterized with other features like tumors of the endocrine glands and skeletal abnormalities. Mutation at codon 918 of the RET protooncogene is a consistent feature among people affected with MEN 2. There are few reports describing pure mucosal neuromas without characteristics of MEN 2B . Analysis of the RET protooncogene among these cases have demonstrated no point mutation in the MEN 2B region (M918T). Hence, it is a subject of debate whether such anomalies should be considered as a different entity or a milder form of the MEN 2B syndrome. We report a case of 25 year old male patient who presented with multiple neuromas over the labial mucosa, tongue and floor of the mouth with no other features of MEN 2B.